Potassium Carbonate → HCID 19913832、化合物

HRID 1090795ノート

反応式

HRID 1090795 の反応式
Cl[CH2:2][C:3]1[CH:20]=[CH:19][C:6]([O:7][CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)=[CH:5][CH:4]=1.[C:21]([C:26]1[O:27][C:28]2[C:33]([C:34](=[O:44])[C:35]=1[C:36]1[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[CH:38][CH:37]=1)=[C:32]([OH:45])[CH:31]=[C:30]([OH:46])[CH:29]=2)([O:23][CH2:24][CH3:25])=[O:22].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:21]([C:26]1[O:27][C:28]2[CH:29]=[C:30]([O:46][CH2:2][C:3]3[CH:20]=[CH:19][C:6]([O:7][CH2:8][C:9]4[CH:18]=[CH:17][C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[N:10]=4)=[CH:5][CH:4]=3)[CH:31]=[C:32]([OH:45])[C:33]=2[C:34](=[O:44])[C:35]=1[C:36]1[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[CH:38][CH:37]=1)([O:23][CH2:24][CH3:25])=[O:22]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 53801872-Carbethoxy-5,7-dihydroxy-4'-methoxyisoflavoneHCID 147741632-(4-Chloromethylphenoxy)methylquinoline

生成物 1

HCID 19913832HCID 19913832、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

0.62 g of 2-(4-chloromethylphenoxy)methyl quinoline, 0.78 g of 2-carboethoxy-5,7-dihydroxy-4'-methoxy isoflavone and 0.31 g potassium carbonate are refluxed in 30 ml of acetone for 17 hours. The mixture was concentrated and the crude product purified by flash chromatography on silica gel and crystallized from toluene to give 2-carboethoxy-5-hydroxy-3-(4-methoxyphenyl)-7-(4-(quinolin-2- ylmethoxy)benzyloxy)-4-oxo-4H-1-benzopyran.

後処理

  1. concentrationThe mixture was concentrated
  2. customthe crude product purified by flash chromatography on silica gel
  3. customcrystallized from toluene

出典と根拠

ORDレコード
ord-6a41f468fcf344dfa0b36018d73ab6b9
出典データセット
uspto-grants-1992_01
特許番号
US05082849

反応ノート

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