Ammonia → HCID 178491593、化合物

HRID 1091021ノート

反応式

HRID 1091021 の反応式
[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=S)[NH:12][C:13](=[O:22])[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)=[O:3].N.OO>CO>[O:3]=[C:2]1[C:4]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:10][C:11]([NH:12][C:13](=[O:22])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[N:1]1

参加物

5

反応物 3

HCID 222AmmoniaHCID 784Hydrogen PeroxideHCID 8928142-[(4-Methoxybenzoyl)carbamothioylamino]benzamide

生成物 1

HCID 178491593HCID 178491593、化合物収率 10.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a stirred mixture of 9.9 g of the above benzamide, 100 ml of methanolic ammonia and 100 ml of methanol was added 22 ml of 30% hydrogen peroxide. The reaction was cooled because of an exotherm and then stirred overnight at room temperature. The solid was collected, partially dissolved in 800 ml of acetonitrile and filtered. The filtrate was chilled, giving 0.95 g of the desired product as white crystals, mp 235°-236° C. (dec.).

後処理

  1. temperatureThe reaction was cooled because of an exotherm
  2. customThe solid was collected
  3. dissolutionpartially dissolved in 800 ml of acetonitrile
  4. filtrationfiltered
  5. temperatureThe filtrate was chilled

出典と根拠

ORDレコード
ord-794b6dc04f7a436389072b3e9f0f8a8a
出典データセット
uspto-grants-1992_01
特許番号
US05084457

反応ノート

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