Fluticasone Propionate → Fluticasone

HRID 1091229

反応式

HRID 1091229 の反応式
CCC([O:5][C@@:6]1([C:30]([S:32][CH2:33][F:34])=[O:31])[C@@:10]2([CH3:28])[CH2:11][C@H:12]([OH:27])[C@:13]3([F:26])[C@:23]4([CH3:24])[C:17](=[CH:18][C:19]([CH:21]=[CH:22]4)=[O:20])[C@@H:16]([F:25])[CH2:15][C@H:14]3[C@@H:9]2[CH2:8][C@H:7]1[CH3:29])=O>O.CS(C)=O.CN(C)C=O.CO.C(O)C>[CH3:29][C@H:7]1[C@:6]([OH:5])([C:30]([S:32][CH2:33][F:34])=[O:31])[C@:10]2([CH3:28])[C@H:9]([C@H:14]3[C@:13]([F:26])([C@@H:12]([OH:27])[CH2:11]2)[C@:23]2([CH3:24])[C:17](=[CH:18][C:19]([CH:21]=[CH:22]2)=[O:20])[C@@H:16]([F:25])[CH2:15]3)[CH2:8]1

参加物

7

反応物 1

HCID 444036Fluticasone Propionate3 回

生成物 1

HCID 5311101Fluticasone

試薬・触媒・溶媒 5

HCID 679Dimethyl Sulfoxide溶媒HCID 702Ethanol溶媒HCID 887Methanol溶媒HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

Preferably, the intranasal steroid of the present formulations is fluticasone propionate. Fluticasone propionate is a synthetic corticosteroid and has the empirical formula C25H31F3O5S. It has the chemical name S-(fluromethyl)6α,9-difluoro-11β-17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate, 17-propionate. Fluticasone propionate is a white to off-white powder with a molecular weight of 500.6 and is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.

出典と根拠

ORDレコード
ord-73fa05b8d3b248268b81ebe76ad62501
出典データセット
uspto-grants-2012_03
特許番号
US08129364B2

関連ノート

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