tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate → (R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride

HRID 1091270ノート

反応式

HRID 1091270 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C@H:11]2[CH2:15][CH2:14][CH2:13][N:12]2C(OC(C)(C)C)=O)=[O:10])=[CH:4][CH:3]=1>Cl.O1CCOCC1>[Cl-:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C@H:11]2[CH2:15][CH2:14][CH2:13][NH2+:12]2)=[O:10])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 9138711tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate

生成物 1

HCID 86607080(R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

4.00 g (12.3 mmol) of tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate are dissolved in 20 ml of 4N HCl in dioxane and left at room temperature for 2 hours. The reaction mixture is evaporated and dried, giving (R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride as a slightly brownish solid; ESI 225.

後処理

  1. customThe reaction mixture is evaporated
  2. customdried

出典と根拠

ORDレコード
ord-97a63253abbc4eb99036d1868721737c
出典データセット
uspto-grants-2012_03
特許番号
US08129373B2

反応ノート

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