3-Benzyloxy-5-(4-fluoro-benzylcarbamoyl)-4-oxo-1-(2-oxo-ethyl)-1,4-dihydro-pyridine-2-carboxylic acid methyl ester → HCID 54713626、化合物
反応式
COC(C1N(CC=O)C=C(C(=O)NCC2C=CC(F)=CC=2)C(=O)C=1OCC1C=CC=CC=1)=O.Cl.Cl.N[C@@H](C)CCNC.[F:43][C:44]1[CH:49]=[CH:48][C:47]([CH2:50][NH:51][C:52]([C:54]2[C:55](=[O:79])[C:56]([O:71]CC3C=CC=CC=3)=[C:57]3[C:68](=[O:69])[N:61]4[C@@H:62]([CH3:67])[CH2:63][CH2:64][N:65]([CH3:66])[C@@H:60]4[CH2:59][N:58]3[CH:70]=2)=[O:53])=[CH:46][CH:45]=1>>[F:43][C:44]1[CH:49]=[CH:48][C:47]([CH2:50][NH:51][C:52]([C:54]2[C:55](=[O:79])[C:56]([OH:71])=[C:57]3[C:68](=[O:69])[N:61]4[C@@H:62]([CH3:67])[CH2:63][CH2:64][N:65]([CH3:66])[C@@H:60]4[CH2:59][N:58]3[CH:70]=2)=[O:53])=[CH:46][CH:45]=1参加物
4
実験手順
In a similar manner to that described in example Z-35, from 16 (18 mg, 0.0398 mmol) and [(3S)-3-aminobutyl]methylamine bis-hydrochloride (19 mg, 0.109 mmol, (4S,12aS)—N-[(4-fluorophenyl)methyl]-1,4-dimethyl-6,8-dioxo-7-[(phenylmethyl)oxy]-1,2,3,4,6,8,12,12a-octahydropyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidine-9-carboxamide was prepared as a white solid. This material was deprotected in a second step similar to that described in example Z-37 to give the title compound as a tan solid (7 mg, 44% 2 steps). 1H NMR (CDCl3) δ 12.53 (s, 1H), 10.47 (s, 1H), 8.29 (s, 1H), 7.32 (m, 2H), 6.99 (m, 2H), 5.04 (1H), 4.60 (m, 2H), 4.23 (s, 3H), 2.83-2.80 (m, 2H), 2.32 (s, 3H), 2.13 (m, 1H), 1.48 (m, 1H), 1.34 (m, 3H); ES+ MS: 415 (M+1).