Hydrochloric Acid → 2-(Piperazin-1-yl)propan-1-ol

HRID 1092109ノート

反応式

HRID 1092109 の反応式
[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)[CH3:4].Cl.O1CCOCC1>C(OCC)(=O)C.CO.CCOCC>[N:5]1([CH:3]([CH3:4])[CH2:2][OH:1])[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 50987509Tert-butyl 4-(1-hydroxypropan-2-yl)piperazine-1-carboxylate

生成物 1

HCID 706292-(Piperazin-1-yl)propan-1-ol収率 113.8%

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A suspension of tert-butyl 4-(1-hydroxypropan-2-yl)piperazine-1-carboxylate (0.782 g, 3.2 mmol) in a mixture of ethyl acetate (10 ml) and methanol (10.00 mL), was treated drop-wise with 4.0M HCl in dioxane (12.00 ml, 48.00 mmol) at room temperature. The reaction mixture was stirred for 18 h. The reaction mixture was diluted with ether and the white solid filtered off, washed with ether and air dried to give 2-(piperazin-1-yl)propan-1-ol (0.525 g, 76%), as its dihydrochloride salt.

後処理

  1. filtrationthe white solid filtered off
  2. washwashed with ether and air
  3. customdried

出典と根拠

ORDレコード
ord-db14603bad0841dd80f7bf3fa8cefc11
出典データセット
uspto-grants-2012_03
特許番号
US08129391B2

反応ノート

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