Hydrochloric Acid → HCID 57495632、化合物
反応式
C(OC(=O)[NH:7][C:8]1([CH2:13][NH:14][CH:15]2[CH:22]3[CH2:23][C:18]4([OH:26])[CH2:19][C:20]([OH:25])([CH2:24][CH:16]2[CH2:17]4)[CH2:21]3)[CH2:12][CH2:11][CH2:10][CH2:9]1)(C)(C)C.Cl>CO>[NH2:7][C:8]1([CH2:13][NH:14][CH:15]2[CH:22]3[CH2:21][C:20]4([OH:25])[CH2:19][C:18]([OH:26])([CH2:17][CH:16]2[CH2:24]4)[CH2:23]3)[CH2:12][CH2:11][CH2:10][CH2:9]1参加物
4
実験手順
A mixture of {1-[(5,7-dihydroxy-adamantan-2-ylamino)-methyl]-cyclopentyl}-carbamic acid tert-butyl ester (350 mg, obtained in examples 122, step A) and 6N HCl solution (1.0 ml) in MeOH (2.0 ml) was stirred at room temperature for 16 hr. The mixture was evaporated. The residue was purified with amine-coated silica gel chromatography (CH2Cl2:MeOH=from 100:0 to 9:1) to obtain the title compound (250 mg, 97%) as a dark brown solid.