(2R)-chloro-3-phenylpropionic acid → (S)-2-acetylthio-3-phenylpropanoic acid

HRID 10929

反応式

HRID 10929 の反応式
[C:1]([O-:4])(=[S:3])[CH3:2].[K+].Cl[C@H:7]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:8]([OH:10])=[O:9]>CN1CCCC1=O>[C:1]([S:3][C@@H:7]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])[CH3:2]

参加物

4

反応物 2

HCID 11458104(2R)-chloro-3-phenylpropionic acidHCID 23670855Potassium ethanethioate

生成物 1

HCID 10176891(S)-2-acetylthio-3-phenylpropanoic acid収率 94.4%

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

Potassium thioacetate (93 mg, 0.81 mmol) was added to a solution of 100 mg (0.54 mmol) of (2R)-2-chloro-3-phenylpropionic acid in 2 ml of N-methyl-2-pyrrolidone at room temperature, and the mixture was stirred for 24 hours. The work-up procedure in the same manner as in Example 18 of the reaction mixture was followed to give 114 mg (0.51 mmol, yield 94%) of the desired (2S)-2-acetylthio-3-phenylpropionic acid.

出典と根拠

ORDレコード
ord-6ac7e1c187a74ce1bb0d90b6c53ef431
出典データセット
uspto-grants-2006_08
特許番号
US07094926B2

関連ノート

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