1-(p-Methoxyphenyl)-2-propanone → N-[5-(4-Fluoro-3-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

HRID 1092961ノート

反応式

HRID 1092961 の反応式
[F:1]C1C=CC(CC(=O)C)=CC=1.FC1C=CC(CC(=O)C)=CC=1S(Cl)(=O)=O.CO[C:29]1[CH:34]=[CH:33][C:32]([C:35]2[S:39][C:38]([NH:40][C:41](=[O:43])[CH3:42])=[N:37][C:36]=2[CH3:44])=[CH:31][C:30]=1[S:45](=[O:48])(=[O:47])[NH2:46].COC1C=CC(CC(=O)C)=CC=1>>[F:1][C:29]1[CH:34]=[CH:33][C:32]([C:35]2[S:39][C:38]([NH:40][C:41](=[O:43])[CH3:42])=[N:37][C:36]=2[CH3:44])=[CH:31][C:30]=1[S:45](=[O:48])(=[O:47])[NH2:46]

参加物

5

反応物 4

HCID 312311-(p-Methoxyphenyl)-2-propanoneHCID 521187(4-Fluorophenyl)acetoneHCID 858617322-Fluoro-5-(2-oxo-propyl)-benzenesulfonyl chlorideHCID 86598407N-[5-(4-Methoxy-3-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

生成物 1

HCID 85861686N-[5-(4-Fluoro-3-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

実験手順

The title compound is prepared from 4-fluorophenyl acetone via 2-fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride (Example 47a) following an identical sequence of reactions used for the synthesis of N-[5-(4-methoxy-3-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 30) from 4-methoxyphenyl acetone.

出典と根拠

ORDレコード
ord-fe1143120d714b9796a9629dd6cf8e01
出典データセット
uspto-grants-2012_03
特許番号
US08129541B2

反応ノート

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