Thiourea → 4-Methyl-5-(3-nitro-phenyl)-thiazol-2-ylamine

HRID 1092983ノート

反応式

HRID 1092983 の反応式
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1)[C:3](=O)[CH3:4].[NH2:15][C:16]([NH2:18])=[S:17]>C(O)C>[CH3:4][C:3]1[N:15]=[C:16]([NH2:18])[S:17][C:2]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1

参加物

4

反応物 2

HCID 2723790ThioureaHCID 85861734HCID 85861734、化合物

生成物 1

HCID 183229114-Methyl-5-(3-nitro-phenyl)-thiazol-2-ylamine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

A stirred solution of 1-Bromo-1-(3-nitro-phenyl)-propan-2-one (98a) (2.4 g, 9.3 mmol) in ethanol (20 ml) at room temperature is treated with thiourea (0.71 g, 9.3 mmol). The reaction mixture is heated to 70° C. for 10 minutes. The resulting precipitate is removed by filtration and dried under vacuum to give the titled compound.

後処理

  1. customThe resulting precipitate is removed by filtration
  2. customdried under vacuum

出典と根拠

ORDレコード
ord-1c6cbfdd0fcc4e728c8e78f5648bef0b
出典データセット
uspto-grants-2012_03
特許番号
US08129541B2

反応ノート

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