Diisopropylethylamine → 4-{3-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-ureido)-butyric acid ethyl ester

関与物質

役割	名称	HCID	仕込み量
反応物	Diisopropylethylamine	HCID 81531	—
反応物	Ethyl 4-isocyanatobutyrate	HCID 3445674	—
反応物	5-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amine	HCID 57351277	—
溶媒	Dichloromethane	HCID 6344	—
生成物	4-{3-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-ureido)-butyric acid ethyl ester	HCID 86598431	—

反応手順

5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Example 72), (0.1 g, 0.31 mmol) DIPEA (0.039 ml, 0.34 mmol), ethyl-4-isocyanatobutyrate (0.046 ml, 0.31 mmol) in DCM (2 ml) are heated together at reflux overnight. The reaction mixture is diluted with DCM (20 ml) and washed with 1M hydrochloric acid (15 ml), water (2×15 ml), brine (15 ml), dried over MgSO4, filtered and concentrated in vacuo to yield the titled compound as an off white solid.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08129541B2
出典データセット	uspto-grants-2012_03
ORD ID	ord-87c2adc378b748ea86a9ec2a8f884ed2
出典メモ	uspto-grants-2012_03