関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| 反応物 | 4-(1-Triisopropylsilanyl-1H-pyrrol-3-ylmethyl)-morpholine | HCID 66636760 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(1H-Pyrrol-3-ylmethyl)-morpholine | HCID 57587018 | — |
反応手順
To a solution of the compound obtained in Step A (75 mmoles) in THF (100 ml) there is added, dropwise, at 0° C., Bu4NF 1.0M in THF (75.0 mmoles). After stirring at 0° C. for one hour, the solution is poured onto ice and is then extracted with DCM. The organic phases are combined and then washed with saturated aqueous NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness to yield the title product, which is used directly in the next Step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08133889B2 |
|---|
| 出典データセット | uspto-grants-2012_03 |
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| ORD ID | ord-d73769b6873c49feb8d2191713e330e3 |
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| 出典メモ | uspto-grants-2012_03 |
|---|
