p-Chlorophenacyl bromide → 1-(4-Chlorophenyl)-2-hydroxyethan-1-one

HRID 1094006

反応式

HRID 1094006 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].C([O-])=[O:13].[K+]>CO>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][OH:13])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 68303p-Chlorophenacyl bromideHCID 2735122Potassium Formate

生成物 1

HCID 5870851-(4-Chlorophenyl)-2-hydroxyethan-1-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (100 mmoles) and potassium formate (130 mmoles) in MeOH (100 ml) is stirred at reflux for 3 hours. The reaction mixture is poured onto crushed ice. The solid formed is filtered off, washed with cold MeOH and then dried in vacuo to yield the title product, which is used directly in the next Step.

後処理

  1. temperatureat reflux for 3 hours
  2. additionThe reaction mixture is poured
  3. customonto crushed ice
  4. customThe solid formed
  5. filtrationis filtered off
  6. washwashed with cold MeOH
  7. customdried in vacuo

出典と根拠

ORDレコード
ord-94a9d4d27d194b6e99e35fecac8bb8ed
出典データセット
uspto-grants-2012_03
特許番号
US08133889B2

関連ノート

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