5-(3-Chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid → (r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid{1-[5-(3-chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-piperidin-3-yl}-amide

HRID 1094272ノート

反応式

HRID 1094272 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14]([OH:16])=O)[CH:5]=[CH:6][CH:7]=1.[NH:17]1[CH2:22][CH2:21][CH2:20][C@@H:19]([NH:23][C:24]([C:26]2[N:33]3[C:29]([S:30][CH:31]=[CH:32]3)=[N:28][C:27]=2[CH3:34])=[O:25])[CH2:18]1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14]([N:17]2[CH2:22][CH2:21][CH2:20][C@@H:19]([NH:23][C:24]([C:26]3[N:33]4[C:29]([S:30][CH:31]=[CH:32]4)=[N:28][C:27]=3[CH3:34])=[O:25])[CH2:18]2)=[O:16])[CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 532711925-(3-Chloro-phenyl)-2-methyl-thiazole-4-carboxylic acidHCID 66639497(r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid piperidin-3-ylamide

生成物 1

HCID 24963754(r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid{1-[5-(3-chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-piperidin-3-yl}-amide

実験手順

prepared by reaction of 5-(3-chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid with (R)-6-methyl-imidazo[2,1-b]-thiazole-5-carboxylic acid-piperidin-3-ylamide.

出典と根拠

ORDレコード
ord-161357fd39884a979f6511ac9b3f691f
出典データセット
uspto-grants-2012_03
特許番号
US08133901B2

反応ノート

読み込み中…