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5-Amino-2-methylpyridine → (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(6-methyl-pyridin-3-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Amino-2-methylpyridine | HCID 243313 | — |
| 反応物 | 2-(4-Fluorophenyl)-2-oxoacetic Acid | HCID 579440 | — |
| 反応物 | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| 生成物 | (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(6-methyl-pyridin-3-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide | HCID 58007552 | — |
反応手順
In analogy to example 47, steps 2, 3 & 4, 6-Methyl-pyridin-3-ylamine, (6-Trifluoromethyl-pyridin-3-yl)-acetonitrile & (4-Fluoro-phenyl)-oxo-acetic acid were successively coupled and reduced to give after separation by chromatography on a chiral column (+ve rotation) the target compound. MS(m/e): 434.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08133909B2 |
| 出典データセット | uspto-grants-2012_03 |
| ORD ID | ord-9b4a7c427a3346b986d99cfd938fc439 |
| 出典メモ | uspto-grants-2012_03 |