Acetic Acid → 5-(Methoxymethyl)isoxazole-4-carboxylic acid
反応式
[CH3:1][O:2][CH2:3][C:4]1[O:8][N:7]=[CH:6][C:5]=1[C:9]([O:11]C)=[O:10].Cl.C(O)(=O)C.O>CC(C)=O>[CH3:1][O:2][CH2:3][C:4]1[O:8][N:7]=[CH:6][C:5]=1[C:9]([OH:11])=[O:10]参加物
6
実験手順
Methyl 5-(methoxymethyl)isoxazole-4-carboxylate (Preparation 42, 1.8 g, 11 mmol) was stirred in a 1:1:1 mixture of concentrated hydrochloric acid (2 ml), acetic acid (2 ml) and water (2 ml) at reflux for 6 hours. Acetone (6 ml) was added and the mixture concentrated in vacuo. The solid residue was triturated with ethyl acetate and the filtrate concentrated in vacuo to afford the title compound as an off white solid (1.4 g, 85% yield).
後処理
- temperatureat reflux for 6 hours
- concentrationthe mixture concentrated in vacuo
- customThe solid residue was triturated with ethyl acetate
- concentrationthe filtrate concentrated in vacuo
出典と根拠
- ORDレコード
- ord-ba0c447e30bf4982a99d930cff454302
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08134007B2
反応ノート
読み込み中…