2-Bromoethanol → 2-[4-(3-Bromo-phenyl)-piperidin-1-yl]-ethanol
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Br[CH2:15][CH2:16][OH:17].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:15][CH2:16][OH:17])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
4-(3-Bromo-phenyl)-piperidine (1.2 g, 4.8 mmol) and 2-bromoethanol (0.72 mL, 10 mmol) were diluted with DMF (20 mL) and treated with potassium carbonate (2.7 g, 20 mmol). These were stirred at ambient temperature for 18 then poured onto water and extracted with ethyl acetate. Organic phase then washed with brine, dried over sodium sulfate, filtered and evaporated to clear oil (0.6 g, 44%).
後処理
- additionthen poured onto water
- extractionextracted with ethyl acetate
- washOrganic phase then washed with brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporated to clear oil (0.6 g, 44%)
出典と根拠
- ORDレコード
- ord-acb44f1e4fbf4dc3b6c1f5ee129d5ae4
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08133900B2
反応ノート
読み込み中…