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Acetyl chloride → 1-[5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)-phenyl]-3-trimethylsilyoxy-2-aza-1,3-butadiene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Trimethylsilane | HCID 70435 | — |
| 反応物 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 反応物 | 5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)benzaldehyde | HCID 57743182 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 1-[5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)-phenyl]-3-trimethylsilyoxy-2-aza-1,3-butadiene | HCID 66641230 | — |
反応手順
In a manner similar to the method described in Example 112b, 5-fluoro-2-(tetrahydro-thiopyran-4-yloxy)-benzaldehyde was treated with LHMDS, acetyl chloride, triethylamine and trimethyl silane to give the desired compound, which was directly used for the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08134001B2 |
| 出典データセット | uspto-grants-2012_03 |
| ORD ID | ord-3ae3bfe9706b46dcb457e63e0b627a3d |
| 出典メモ | uspto-grants-2012_03 |