2-Chloro-5-(trifluoromethyl)benzaldehyde → HCID 66641220、化合物

反応式

[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:14]=1[CH:15]=O>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[CH:15][C:14]3[CH:17]=[C:18]([C:21]([F:22])([F:24])[F:23])[CH:19]=[CH:20][C:13]=3[Cl:12])[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 6881812-Chloro-5-(trifluoromethyl)benzaldehyde

HCID 7363446-Chloro-1,3-dihydroindol-2-one

生成物 1

HCID 66641220HCID 66641220、化合物

実験手順

In a manner similar to the methods described in Examples 1a and 1b, 6-chloro-1,3-dihydro-indol-2-one (Aldrich) reacted with 2-chloro-5-trifluoromethyl-benzaldehyde (Aldrich) to give 6-chloro-3-[1-(2-chloro-5-trifluoromethyl-phenyl)-methylidene]-2-oxo-2,3-dihydro-indole, which was subsequently reacted with di-tert-butyl-dicarbonate and DMAP and directly used for the next step.

出典と根拠

ORDレコード: ord-66c4c4242ac0428aad8a791daf7741d0
出典データセット: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08134001B2

反応ノート

読み込み中…

参加物