Sulfuric Acid → 4,6-Dichloroisatin

HRID 1095519

反応式

HRID 1095519 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:14])[CH:11]=NO)[CH:5]=[C:6]([Cl:8])[CH:7]=1.S(=O)(=O)(O)[OH:16]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]2[C:3]=1[C:11](=[O:16])[C:10](=[O:14])[NH:9]2

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 71353147N-(3,5-Dichlorophenyl)-2-(hydroxyimino)acetamide

生成物 1

HCID 2519084,6-Dichloroisatin収率 81%

反応条件

温度
90 °C

実験手順

The N-(3,5-dichlorophenyl)-2-hydroxyiminoacetamide just prepared (12.1 g, 0.052 mol) was added to 96 per cent strength sulfuric acid (56 ml) at 50-75° C. in the course of 15 min. The reaction mixture was then heated at 90° C. for 15 min, while stirring. After cooling, the mixture was poured slowly on to ice (500 g). The solid formed was filtered off with suction after 30 min. The desired isatin was isolated in a yield of 81% (9.12 g) as an orange-coloured solid. It was not possible to determine a melting point.

後処理

  1. temperatureAfter cooling
  2. customThe solid formed
  3. filtrationwas filtered off with suction after 30 min

出典と根拠

ORDレコード
ord-1945cd6d6fdf4c8a945f9b5cb2a0e64c
出典データセット
uspto-grants-2012_03
特許番号
US08138187B2

関連ノート

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