関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phosphorus oxybromide | HCID 24613 | — |
| 反応物 | 8-Bromo-1,2-dihydroquinolin-2-one | HCID 10933094 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2,8-Dibromoquinoline | HCID 45925951 | 80% |
反応手順
A mixture of 8-bromoquinolin-2(1H)-one (5 g, 22 mmol) and phosphoryl tribromide (13 g, 45 mmol) was heated to 140° C. for three hours. The resulting mixture was poured onto 100 g of ice and 100 ml water. The mixture was stirred for 1 hour and the resulting solids were filtered to yield the title compound. (5.1 g, 80% yield) MS APCI (+) 286, 288, and 290 (M+1 of each isotope combination) detected.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08138181B2 |
|---|
| 出典データセット | uspto-grants-2012_03 |
|---|
| ORD ID | ord-f295163c5eb74fd1b7e6855b6c336ce1 |
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| 出典メモ | uspto-grants-2012_03 |
|---|
