Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate → 3-Fluoropiperidin-4-one hydrochloride
反応式
[F:1][CH:2]1[C:7](=[O:8])[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:16].O1CCOCC1>CCOC(C)=O>[ClH:16].[F:1][CH:2]1[C:7](=[O:8])[CH2:6][CH2:5][NH:4][CH2:3]1参加物
4
実験手順
To a hazy solution of tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate (52.66 g, 242 mmol) in EtOAc (1 L) was added 4M HCl/dioxane (303 mL, 1212 mmol). The mixture was allowed to stir at ambient temperature for 16 hours. The resulting precipitate was collected by filtration, washed with EtOAc and dried in vacuo to afford 37 g (99%) of desired product as a solid.
後処理
- filtrationThe resulting precipitate was collected by filtration
- washwashed with EtOAc
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-b4fbdf22149544bd8b3264cde8c723f8
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08138181B2
反応ノート
読み込み中…