Chloroacetaldehyde → 7-Ethylimidazo[1,2-a]pyridine

HRID 1095738ノート

反応式

HRID 1095738 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([NH2:9])[CH:4]=1)[CH3:2].Cl[CH2:11][CH:12]=O>CCO>[CH2:1]([C:3]1[CH:8]=[CH:7][N:6]2[CH:11]=[CH:12][N:9]=[C:5]2[CH:4]=1)[CH3:2]

参加物

4

反応物 2

HCID 33ChloroacetaldehydeHCID 1184254-Ethylpyridin-2-amine

生成物 1

HCID 181844637-Ethylimidazo[1,2-a]pyridine収率 98.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4-ethylpyridin-2-amine (3.21 g, 8.19 mmol), and chloroacetaldehyde (50% aqueous solution, 2.6 ml, 10.5 mmol) in EtOH (10 ml) was refluxed vigorously for 12 hours. The reaction mixture was concentrated, and the residue was suspended in saturated aqueous sodium bicarbonate solution. The aqueous mixture was extracted with CH2Cl2 and EtOAc, and the combined organic extracts were dried over Na2SO4, filtered and concentrated to afford the desired product (1.18 g, 98% yield) as a viscous oil. MS APCI (+) m/z 147.2 (M+1) detected.

後処理

  1. temperaturewas refluxed vigorously for 12 hours
  2. concentrationThe reaction mixture was concentrated
  3. extractionThe aqueous mixture was extracted with CH2Cl2 and EtOAc
  4. dry with materialthe combined organic extracts were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-a14ef65495744592aceb2fbe75dcfb13
出典データセット
uspto-grants-2012_03
特許番号
US08138181B2

反応ノート

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