化工社化工社 化学情報印刷レポート · 研究参考用
3-Chloro-4-(methoxycarbonyl)benzeneboronic acid → 2-Chloro-4-{3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-propyl]-phenoxy}-benzoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloro-4-(methoxycarbonyl)benzeneboronic acid | HCID 23005335 | — |
| 反応物 | 5-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one | HCID 57421314 | — |
| 触媒 | Cupric acetate | HCID 8895 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2-Chloro-4-{3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-propyl]-phenoxy}-benzoic acid methyl ester | HCID 66699159 | — |
反応手順
In analogy to Example 151, step 8, 5-[2-(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one (Example 151, step 7) was reacted with 3-chloro-4-methoxycarbonylphenylboronic acid, copper-(II)-acetate and pyridine to give the title compound as a colorless solid. MS (m/e)=530.1 [M+H+].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08138189B2 |
| 出典データセット | uspto-grants-2012_03 |
| ORD ID | ord-3e1cc40e5b93456399dd79b9ba46d85c |
| 出典メモ | uspto-grants-2012_03 |