3-Chloro-4-(methoxycarbonyl)benzeneboronic acid → 3,3'-Dichloro-4'-[3,3,3-trifluoro-2-hydroxy-2-(6-methoxy-pyridin-3-yl)-1-methyl-propyl]-biphenyl-4-carboxylic acid methyl ester

HRID 1095995

反応式

HRID 1095995 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:23])[C:9]([C:15]2[CH:16]=[N:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=2)([OH:14])[C:10]([F:13])([F:12])[F:11])=[C:4]([Cl:24])[CH:3]=1.[Cl:25][C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][C:31]=1[C:32]([O:34][CH3:35])=[O:33]>>[CH3:35][O:34][C:32]([C:31]1[CH:30]=[CH:29][C:28]([C:2]2[CH:7]=[CH:6][C:5]([CH:8]([CH3:23])[C:9]([OH:14])([C:15]3[CH:16]=[N:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=3)[C:10]([F:13])([F:12])[F:11])=[C:4]([Cl:24])[CH:3]=2)=[CH:27][C:26]=1[Cl:25])=[O:33]

参加物

3

反応物 2

HCID 230053353-Chloro-4-(methoxycarbonyl)benzeneboronic acidHCID 574213213-(4-Bromo-2-chloro-phenyl)-1,1,1-trifluoro-2-(6-methoxy-pyridin-3-yl)-butan-2-ol

生成物 1

HCID 666990143,3'-Dichloro-4'-[3,3,3-trifluoro-2-hydroxy-2-(6-methoxy-pyridin-3-yl)-1-methyl-propyl]-biphenyl-4-carboxylic acid methyl ester

実験手順

In analogy to Example 150, step 2, 3-(4-bromo-2-chloro-phenyl)-1,1,1-trifluoro-2-(6-methoxy-pyridin-3-yl)-butan-2-ol (Example 175, step 3) was reacted with 3-chloro-4-methoxycarbonylphenylboronic acid to give the title compound as a colorless foam. MS (m/e)=514.4 [M+H+].

出典と根拠

ORDレコード
ord-cea5360bf4764dcaa7115fa306b600ee
出典データセット
uspto-grants-2012_03
特許番号
US08138189B2

関連ノート

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