Triethylamine → 2-(2-Oxazolinyl)pyridine

HRID 1096552ノート

反応式

HRID 1096552 の反応式
[CH2:1]([N:3](CC)CC)[CH3:2].Cl.[NH2:9][C@@H:10]([CH2:13][CH:14]1[CH2:19][CH2:18]CCC1)[CH2:11][OH:12]>C(Cl)Cl>[N:9]1[CH:18]=[CH:19][CH:14]=[CH:13][C:10]=1[C:11]1[O:12][CH2:2][CH2:1][N:3]=1

参加物

4

反応物 2

HCID 8471TriethylamineHCID 16212813(2S)-2-amino-3-cyclohexylpropan-1-ol hydrochloride

生成物 1

HCID 154269572-(2-Oxazolinyl)pyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
50 °C

実験手順

Methyl-6-phenylpyridyl-2-imidate (0.160 g, 0.754 mmol) was dissolved in CH2Cl2 (3 mL). Triethylamine (0.12 mL, 0.83 mmol) was added followed by 2-(S)-amino-3-cyclohexylpropanol hydrochloride (0.161 g, 0.829 mmol). The reaction vessel was sealed and heated on a heating block (50° C.) for 16 hours and the resultant solution was then filtered to remove the insoluble salts. The filtrate was loaded onto the top of a Biotage cartridge (silica gel, 40S) and the product was eluted using a stepped gradient of 0 to 30% ethyl acetate in hexanes as the eluent. The product was obtained after evaporation of the eluent as a slightly yellow solid (0.181 g, 75%).

後処理

  1. customThe reaction vessel was sealed
  2. filtrationthe resultant solution was then filtered
  3. customto remove the insoluble salts
  4. washthe product was eluted
  5. customThe product was obtained
  6. customafter evaporation of the eluent as a slightly yellow solid (0.181 g, 75%)

出典と根拠

ORDレコード
ord-b10be19e57c84d6bb0cfaa769c38af08
出典データセット
uspto-grants-2012_03
特許番号
US08138348B2

反応ノート

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