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6-[Cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-7-[2-(2-hydroxyethoxy)thiazol-5-yl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester → 7-{2-[2-(4-Chloro-1-methyl-5-trifluoromethyl-1H-pyrazol-3-yloxy)-ethoxy]thiazol-5-yl}-6-[cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-[Cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-7-[2-(2-hydroxyethoxy)thiazol-5-yl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester | HCID 68570797 | — |
| 反応物 | HCID 178481948 | HCID 178481948 | — |
| 生成物 | 7-{2-[2-(4-Chloro-1-methyl-5-trifluoromethyl-1H-pyrazol-3-yloxy)-ethoxy]thiazol-5-yl}-6-[cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester | HCID 77516352 | — |
反応手順
This compound is prepared from compound E9 and 4-chloro-1-methyl-5-trifluoromethyl-1H-pyrazol-3-ol (Eur. Pat. Appl., 1989, EP 304409), according to the above-described procedure A. LC-MS: tR=1.23 min, ES+: 867.40.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08138340B2 |
| 出典データセット | uspto-grants-2012_03 |
| ORD ID | ord-e44df897dec84e7ab2176f9ae30d56e8 |
| 出典メモ | uspto-grants-2012_03 |