Hydrochloric Acid → 6-(6-Oxo-1,6-dihydropyridin-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

HRID 1096930ノート

反応式

HRID 1096930 の反応式
C[O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[C:28](=[CH:29][CH:30]=2)[O:27][C:14]2([CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)[CH2:13][C:12]3=[O:31])=[CH:5][CH:4]=1.[ClH:32]>>[ClH:32].[O:2]=[C:3]1[NH:8][CH:7]=[C:6]([C:9]2[CH:10]=[C:11]3[C:28](=[CH:29][CH:30]=2)[O:27][C:14]2([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH2:13][C:12]3=[O:31])[CH:5]=[CH:4]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 57930941Tert-Butyl 6-[6-(methoxy)pyridin-3-yl]-4-oxo-spiro[chroman-2,4'-piperidine]-1'-carboxylate

生成物 1

HCID 667818066-(6-Oxo-1,6-dihydropyridin-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

実験手順

Tert-Butyl 6-[6-(methoxy)pyridin-3-yl]-4-oxo-spiro[chroman-2,4′-piperidine]-1′-carboxylate (550 mg) was suspended in conc. HCl aq. (10 ml) and stirred at 100 deg. for 20 h. After removal of the solvent, the resulted solid was washed with MeOH and Et2O to obtain the intended compound as a colorless solid.

後処理

  1. customAfter removal of the solvent
  2. washthe resulted solid was washed with MeOH and Et2O

出典と根拠

ORDレコード
ord-7afb32bd2310406d95e54586a7e82680
出典データセット
uspto-grants-2012_03
特許番号
US08138197B2

反応ノート

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