Triethyl orthoacetate → Methyl 4-(2-methyl-1,3-oxazol-5-yl)-3,5-dimethoxybenzoate

HRID 1096989ノート

反応式

HRID 1096989 の反応式
Cl.[NH2:2][CH2:3][C:4]([C:6]1[C:15]([O:16][CH3:17])=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][C:7]=1[O:18][CH3:19])=[O:5].[C:20](OCC)(OCC)(OCC)[CH3:21]>>[CH3:20][C:21]1[O:5][C:4]([C:6]2[C:7]([O:18][CH3:19])=[CH:8][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:14][C:15]=2[O:16][CH3:17])=[CH:3][N:2]=1

参加物

3

反応物 2

HCID 66221Triethyl orthoacetateHCID 66782707Methyl 4-(aminoacetyl)-3,5-dimethoxybenzoate hydrochloride

生成物 1

HCID 57930976Methyl 4-(2-methyl-1,3-oxazol-5-yl)-3,5-dimethoxybenzoate

反応条件

温度
140 °C

実験手順

Methyl 4-(aminoacetyl)-3,5-dimethoxybenzoate hydrochloride was dissolved in triethyl orthoacetate, paratoluenesulfonic acid monohydrate (10 mg) was added to it, and stirred at 140° C. for 6 hours. The reaction liquid was cooled to room temperature, then triethyl orthoacetate was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (hexane/ethyl acetate=100/0 to 30/70) to obtain the title compound.

後処理

  1. customThe reaction liquid
  2. temperaturewas cooled to room temperature
  3. customtriethyl orthoacetate was evaporated away under reduced pressure
  4. customthe residue was purified through silica gel column chromatography (hexane/ethyl acetate=100/0 to 30/70)

出典と根拠

ORDレコード
ord-01dc5985ce724fab93919cb95bc03515
出典データセット
uspto-grants-2012_03
特許番号
US08138197B2

反応ノート

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