Formic Acid → HCID 86634878、化合物

HRID 1097072ノート

反応式

HRID 1097072 の反応式
[C:1](OC(=O)C)(=[O:3])C.C(O)=O.[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:14][CH:13]=1>C(=O)(O)[O-].[Na+]>[CH3:22][O:21][C:19](=[O:20])[CH2:18][C:15]1[CH:14]=[CH:13][C:12]([NH:11][CH:1]=[O:3])=[CH:17][CH:16]=1

参加物

5

反応物 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 2761030Methyl 2-(4-aminophenyl)acetate

生成物 1

HCID 86634878HCID 86634878、化合物収率 73.6%

試薬・触媒・溶媒 1

HCID 516892Sodium Bicarbonate溶媒

実験手順

A solution of acetic anhydride (14.3 mL, 151 mmol) and formic acid (22.8 mL, 605 mmol) was stirred at room temperature for 1 h. Methyl (4-aminophenyl)acetate (5.00 g, 30.3 mmol) was added and the resulting mixture was stirred overnight. Saturated aqueous sodium bicarbonate (10 mL) was added and the resulting mixture was extracted with DCM (2×10 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated under reduced pressure to give the title compound (4.31 g) as a yellow oil, which was used in the next reaction without further purification.

後処理

  1. extractionthe resulting mixture was extracted with DCM (2×10 mL)
  2. dry with materialThe combined organic layers were dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-971908a6bd234306997619c47b0435cc
出典データセット
uspto-grants-2012_03
特許番号
US08138345B2

反応ノート

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