Tert-Butylamine → N-t-Butyl 3-bromobenzamide

HRID 1097120ノート

反応式

HRID 1097120 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[C:11]([NH2:15])([CH3:14])([CH3:13])[CH3:12]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:15][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:6]

参加物

4

反応物 2

HCID 6385Tert-ButylamineHCID 74377Benzoyl chloride, 3-bromo-

生成物 1

HCID 603211N-t-Butyl 3-bromobenzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 3-bromo-benzoyl chloride (0.83 g, 3.8 mmol) in DCM (10 mL) was chilled to zero degrees and treated with tert-butylamine (1.2 mL, 11.3 mmol). Reaction was allowed to come to room temperature and stir for 4 h. Mixture was then poured onto water and washed once. Organic phase then washed with brine, dried over sodium sulfate, filtered and evaporated to amber oil (0.9 g, 94%).

後処理

  1. customReaction
  2. customto come to room temperature
  3. additionMixture was then poured onto water
  4. washwashed once
  5. washOrganic phase then washed with brine
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. customevaporated to amber oil (0.9 g, 94%)

出典と根拠

ORDレコード
ord-fe8b9146f04c4760b83e4a86d2df9fae
出典データセット
uspto-grants-2012_03
特許番号
US08138199B2

反応ノート

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