Dimethylformamide → 2,6-Diisopropyl-4-bromobenzaldehyde

HRID 1097161ノート

反応式

HRID 1097161 の反応式
I[C:2]1[C:7]([CH:8]([CH3:10])[CH3:9])=[CH:6][C:5]([Br:11])=[CH:4][C:3]=1[CH:12]([CH3:14])[CH3:13].[Li]CCCC.CN([CH:23]=[O:24])C>C1(C)C=CC=CC=1>[CH:12]([C:3]1[CH:4]=[C:5]([Br:11])[CH:6]=[C:7]([CH:8]([CH3:10])[CH3:9])[C:2]=1[CH:23]=[O:24])([CH3:14])[CH3:13]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 574376675-Bromo-2-iodo-1,3-diisopropylbenzeneHCID 178418339Butyllithium

生成物 1

HCID 574376682,6-Diisopropyl-4-bromobenzaldehyde

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

A 150 mL of dry toluene solution of 1-iodo-2,6-diisopropyl-4-bromobenzene (17.6 g, 0.048 mol) was treated with n-BuLi (1.6 M in hexane, 75 mL) at −78° C. in 30 minutes. After stirring for 15 minutes, dry DMF (20 mL) in 50 mL of toluene was added dropwise. The resulting mixture was slowly warmed up to room temperature. After regular work up, the crude product was distilled at 140° C. under vacuum to afford 2,6-diisopropyl-4-bromobenzaldehyde (11.5 g).

後処理

  1. distillationAfter regular work up, the crude product was distilled at 140° C. under vacuum

出典と根拠

ORDレコード
ord-77df41682c48435fbd7b9f1b93ceb0a9
出典データセット
uspto-grants-2012_03
特許番号
US08142909B2

反応ノート

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