tert-Butyl 4-(4-aminophenyl)piperidine-1-carboxylate → 4-{4-[8-(2-Fluoro-3-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester

反応式

[C:20]([CH3:21])([CH3:22])([CH3:23])[O:24][C:25](=[O:26])[N:27]1[CH2:28][CH2:29][CH:30]([c:33]2[cH:34][cH:35][c:36]([NH2:39])[cH:37][cH:38]2)[CH2:31][CH2:32]1.[Cl:1][c:2]1[n:3][n:4]2[c:5]([c:6](-[c:10]3[c:11]([F:18])[c:12]([O:16][CH3:17])[cH:13][cH:14][cH:15]3)[cH:7][cH:8][cH:9]2)[n:19]1>>[c:2]1([NH:39][c:36]2[cH:35][cH:34][c:33]([CH:30]3[CH2:29][CH2:28][N:27]([C:25]([O:24][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:26])[CH2:32][CH2:31]3)[cH:38][cH:37]2)[n:3][n:4]2[c:5]([c:6](-[c:10]3[c:11]([F:18])[c:12]([O:16][CH3:17])[cH:13][cH:14][cH:15]3)[cH:7][cH:8][cH:9]2)[n:19]1

参加物

反応物 2

HCID 21940085tert-Butyl 4-(4-aminophenyl)piperidine-1-carboxylate

HCID 674815542-Chloro-8-(2-fluoro-3-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridine

生成物 1

HCID 498396114-{4-[8-(2-Fluoro-3-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester

出典と根拠

ORDレコード: ord-4e50ea11a95541979beb1176f1e70b6f
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…