1-Ethyl-5-methyl-5-(4,5,6,7-tetrafluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione → 5-Ethyl-1-isopropyl-5-(4,5,6,7-tetrafluoro-1,3-dihydro-1,3-dioxo-2h-isoindol-2-yl)-2,4,6(1h,3h,5h)-pyrimidinetrione

HRID 1097275

反応式

HRID 1097275 の反応式
[NH2:1][C:2]1([CH2:14][CH3:15])[C:7](=[O:8])[N:6]([CH:9]([CH3:11])[CH3:10])[C:5](=[O:12])[NH:4][C:3]1=[O:13].C(N1C(=O)C(C)(N2[C:33](=[O:34])[C:32]3[C:27](=[C:28]([F:38])[C:29]([F:37])=[C:30]([F:36])[C:31]=3[F:35])[C:26]2=[O:39])C(=O)NC1=O)C>>[CH2:14]([C:2]1([N:1]2[C:26](=[O:39])[C:27]3[C:32](=[C:31]([F:35])[C:30]([F:36])=[C:29]([F:37])[C:28]=3[F:38])[C:33]2=[O:34])[C:7](=[O:8])[N:6]([CH:9]([CH3:11])[CH3:10])[C:5](=[O:12])[NH:4][C:3]1=[O:13])[CH3:15]

参加物

3

反応物 2

HCID 247656681-Ethyl-5-methyl-5-(4,5,6,7-tetrafluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,4,6(1H,3H,5H)-pyrimidinetrioneHCID 668107735-Amino-5-ethyl-1-isopropylbarbituric acid

生成物 1

HCID 247657625-Ethyl-1-isopropyl-5-(4,5,6,7-tetrafluoro-1,3-dihydro-1,3-dioxo-2h-isoindol-2-yl)-2,4,6(1h,3h,5h)-pyrimidinetrione

実験手順

Compound 19g was prepared from 5-amino-5-ethyl-1-isopropylbarbituric acid (0.32 g, 1.50 mmol) using the same procedure described for 19f. The crude product was recrystallized from EtOH to give 5-ethyl-1-isopropyl-5-(tetrafluorophthalimido)barbituric acid (19g) as white crystals.

後処理

  1. customThe crude product was recrystallized from EtOH

出典と根拠

ORDレコード
ord-2809b07b8e9b4928a80badabee8ba996
出典データセット
uspto-grants-2012_03
特許番号
US08143252B2

関連ノート

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