1-Ethyl-5-methyl-5-(4,5,6,7-tetrafluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione → 1-Cyclohexyl-5-methyl-5-(4,5,6,7-tetrafluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione

HRID 1097276

反応式

HRID 1097276 の反応式
[NH2:1][C:2]1([CH3:17])[C:7](=[O:8])[N:6]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[C:5](=[O:15])[NH:4][C:3]1=[O:16].C(N1C(=O)C(C)(N2[C:35](=[O:36])[C:34]3[C:29](=[C:30]([F:40])[C:31]([F:39])=[C:32]([F:38])[C:33]=3[F:37])[C:28]2=[O:41])C(=O)NC1=O)C>>[CH:9]1([N:6]2[C:7](=[O:8])[C:2]([CH3:17])([N:1]3[C:28](=[O:41])[C:29]4[C:34](=[C:33]([F:37])[C:32]([F:38])=[C:31]([F:39])[C:30]=4[F:40])[C:35]3=[O:36])[C:3](=[O:16])[NH:4][C:5]2=[O:15])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

参加物

3

反応物 2

HCID 247656681-Ethyl-5-methyl-5-(4,5,6,7-tetrafluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,4,6(1H,3H,5H)-pyrimidinetrioneHCID 668107655-Amino-1-cyclohexyl-5-methylbarbituric acid

生成物 1

HCID 247657601-Cyclohexyl-5-methyl-5-(4,5,6,7-tetrafluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione

実験手順

Compound 19h was prepared from 5-amino-1-cyclohexyl-5-methylbarbituric acid (0.36 g, 1.50 mmol) using the same procedure described for 19f. The crude product was recrystallized from EtOH to give 1-cyclohexyl-5-methyl-5-(tetrafluorophthalimido)barbituric acid (19h) as white crystals.

後処理

  1. customThe crude product was recrystallized from EtOH

出典と根拠

ORDレコード
ord-a135f5ad152247b083c920ec03f02fa1
出典データセット
uspto-grants-2012_03
特許番号
US08143252B2

関連ノート

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