1-(Bromomethyl)-2,3-difluoro-benzene → HCID 178508256、化合物

HRID 1097330

反応式

HRID 1097330 の反応式
CC(C)([O-])C.[K+].[NH2:7][C:8]1[S:9][C:10]2[C:15](=[O:16])[NH:14][C:13](=[S:17])[NH:12][C:11]=2[N:18]=1.[F:19][C:20]1[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22]Br>CS(C)=O>[NH2:7][C:8]1[S:9][C:10]2[C:15](=[O:16])[N:14]=[C:13]([S:17][CH2:22][C:21]3[CH:24]=[CH:25][CH:26]=[C:27]([F:28])[C:20]=3[F:19])[NH:12][C:11]=2[N:18]=1

参加物

5

反応物 3

HCID 5179841-(Bromomethyl)-2,3-difluoro-benzeneHCID 114583092-amino-5,6-dihydro-5-thioxo-thiazolo[4,5-d]pyrimidin-7(4H)-oneHCID 23665647Potassium tert-butoxide

生成物 1

HCID 178508256HCID 178508256、化合物

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

Potassium t-butoxide solution (0.45 ml of 1M solution in tetrahydrofuran) was added to a stirred solution of 2-amino-5,6-dihydro-5-thioxo-thiazolo[4,5-d]pyrimidin-7(4H)-one (0.09 g) [Cited: Indian J. Chem., Sect. B (1989), 28B(11), 964-5.] and 2,3-difluorobenzyl bromide in dimethyl sulphoxide (2 ml). After stirring for 3 days, the reaction mixture was poured onto water to give and the subtitle compound, isolated by filtration.

後処理

  1. additionthe reaction mixture was poured onto water
  2. customto give

出典と根拠

ORDレコード
ord-41c3cb54a6b1406fafc1c847ad29de30
出典データセット
uspto-grants-2012_03
特許番号
US08143261B2

関連ノート

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