Thiourea → HCID 22671284、化合物

HRID 1097359

反応式

HRID 1097359 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12])[CH2:5]Br.NC(N)=[S:17]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:5][SH:17])[CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12]

参加物

4

反応物 2

HCID 2723790ThioureaHCID 27738494-(Bromomethyl)-2-chloro-1-(trifluoromethoxy)benzene

生成物 1

HCID 22671284HCID 22671284、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 3-chloro-4-(trifluoromethoxy)benzylbromide (5 g) in ethanol (100 ml) was added thiourea (5 g) and the mixture heated under reflux for 2 hours. The mixture was evaporated to dryness and the residue taken up into water (100 ml). To this solution was added sodium hydroxide pellets (3 g) and the mixture heated under reflux for 1 hour. The mixture was allowed to cool to room temperature and acidified with concentrated hydrochloric acid, the mixture was extracted with ether, dried and evaporated to give the subtitle compound as a colourless waxy solid (3.5 g).

後処理

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 2 hours
  3. customThe mixture was evaporated to dryness
  4. additionTo this solution was added sodium hydroxide pellets (3 g)
  5. temperaturethe mixture heated
  6. temperatureunder reflux for 1 hour
  7. extractionthe mixture was extracted with ether
  8. customdried
  9. customevaporated

出典と根拠

ORDレコード
ord-bcf0365a16f44fd1ad39f5ee8d7eebb8
出典データセット
uspto-grants-2012_03
特許番号
US08143261B2

関連ノート

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