Dimethylformamide → HCID 86227722、化合物

HRID 1097583ノート

反応式

HRID 1097583 の反応式
C(N(CC)CC)C.[Cl:8][C:9]1[C:18]([N+:19]([O-:21])=[O:20])=[C:17](Cl)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.CN(C=O)C.Cl.[F:29][C:30]([CH3:34])([CH3:33])[CH2:31][NH2:32]>O>[Cl:8][C:9]1[C:18]([N+:19]([O-:21])=[O:20])=[C:17]([NH:32][CH2:31][C:30]([F:29])([CH3:34])[CH3:33])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 27851382,4-Dichloro-3-nitroquinolineHCID 552896302-Fluoro-2-methylpropan-1-amine hydrochloride

生成物 1

HCID 86227722HCID 86227722、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Triethylamine (2.76 g, 27.3 mmol) was added to a mixture of 2,4-dichloro-3-nitroquinoline (André et al, U.S. Pat. No. 4,988,815, Example 2, 4.44 g, 18.2 mmol) and DMF (50 mL), and then 2-fluoro-2-methylpropan-1-amine hydrochloride (2.5 g, 20 mmol) was added. The reaction was stirred at room temperature overnight and then poured into water (500 mL). The resulting mixture was stirred for 15 minutes. A solid was present and was isolated by filtration to provide 4.8 g of 2-chloro-N-(2-fluoro-2-methylpropyl)-3-nitroquinolin-4-amine as a yellow solid.

後処理

  1. stirringThe resulting mixture was stirred for 15 minutes
  2. customwas isolated by filtration

出典と根拠

ORDレコード
ord-d57f10bd3edc4b13b5d8637086681b4d
出典データセット
uspto-grants-2012_03
特許番号
US08143270B2

反応ノート

読み込み中…