3-benzyloxycarbonylamino-6-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid → 3-benzyloxycarbonylamino-6-ethyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid

HRID 10981

反応式

HRID 10981 の反応式
C(OC(NC1C(=O)N2C(C)(C(O)=O)CCC2=NC=1)=O)C1C=CC=CC=1.C([O:30][C:31]([C:33]1([CH2:54][CH3:55])[N:37]2[C:38](=[O:53])[C:39]([NH:42][C:43]([O:45][CH2:46][C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=3)=[O:44])=[CH:40][N:41]=[C:36]2[CH2:35][CH2:34]1)=[O:32])(C)(C)C>>[CH2:46]([O:45][C:43]([NH:42][C:39]1[C:38](=[O:53])[N:37]2[C:33]([CH2:54][CH3:55])([C:31]([OH:32])=[O:30])[CH2:34][CH2:35][C:36]2=[N:41][CH:40]=1)=[O:44])[C:47]1[CH:48]=[CH:49][CH:50]=[CH:51][CH:52]=1

参加物

3

反応物 2

HCID 219796983-benzyloxycarbonylamino-6-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic AcidHCID 696005493-Benzyloxycarbonylamino-6-ethyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid tert-butyl Ester

生成物 1

HCID 219796213-benzyloxycarbonylamino-6-ethyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid収率 99%

実験手順

According to the procedure for the preparation of intermediate 19b, intermediate 22a (41 mg, 413.47 mmol) was deprotected to afford 35 mg (99%) of intermediate 22b. MS (ESI) 358.3 (M+H+), 356.2 (M−H+).

出典と根拠

ORDレコード
ord-59bf92b943f54d59b86c2b1a12e61f69
出典データセット
uspto-grants-2006_08
特許番号
US07094783B2

関連ノート

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