4-Chloro-1-(2-chlorophenyl)-1H-pyrazolo[3,4-D]pyrimidine → (2S)-methyl 2-(1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-3-isopropoxypropanoate

反応式

[OH:1][C@@H:2]([CH2:7][O:8][CH:9]([CH3:11])[CH3:10])[C:3]([O:5][CH3:6])=[O:4].Cl[C:13]1[N:18]=[CH:17][N:16]=[C:15]2[N:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[Cl:28])[N:20]=[CH:21][C:14]=12>>[Cl:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[N:19]1[C:15]2=[N:16][CH:17]=[N:18][C:13]([O:1][C@@H:2]([CH2:7][O:8][CH:9]([CH3:11])[CH3:10])[C:3]([O:5][CH3:6])=[O:4])=[C:14]2[CH:21]=[N:20]1

参加物

反応物 2

HCID 112655704-Chloro-1-(2-chlorophenyl)-1H-pyrazolo[3,4-D]pyrimidine

HCID 59279510(S)-methyl 2-hydroxy-3-isopropoxypropanoate

生成物 1

HCID 59279536(2S)-methyl 2-(1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-3-isopropoxypropanoate

実験手順

D2a was prepared in an analogous fashion to D1b from (S)-methyl 2-hydroxy-3-isopropoxypropanoate C7a and B1.

出典と根拠

ORDレコード: ord-dcf0295646c5451a8d1e67a5cfd0d99c
出典データセット: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08143263B2

反応ノート

読み込み中…