Imidazole → Methyl 5-(tert-butyl-dimethylsilyl)oxypentanoate

HRID 1098136

反応式

HRID 1098136 の反応式
[C:1]([Si:5](Cl)([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2].[OH:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15].N1C=CN=C1>C(Cl)Cl>[Si:5]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])([C:1]([CH3:4])([CH3:3])[CH3:2])([CH3:7])[CH3:6]

参加物

5

反応物 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 3014818Pentanoic acid, 5-hydroxy-, methyl ester

生成物 1

HCID 11139432Methyl 5-(tert-butyl-dimethylsilyl)oxypentanoate収率 52%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

実験手順

A solution of tert-butylchlorodimethylsilane (27.1 g, 179.79 mmol) in DCM (50 mL) was added dropwise to a stirred solution of methyl 5-hydroxypentanoate (CAS no. 14273-92-8, Huckstep, M.; Taylor, R. J. K.; Caton, M. P. L. Synthesis 1982, 10, 881) (19.8 g, 149.82 mmol) and 1H-imidazole (15.30 g, 224.73 mmol) in DCM (200 mL) at 5° C., over a period of 10 minutes under nitrogen. The resulting suspension was stirred at ambient temperature for 6 hours. The reaction mixture was diluted with DCM (250 mL), and washed sequentially with water (2×200 mL) and saturated brine (200 mL). The organic layer was dried (MgSO4) and evaporated. The residue was purified by flash silica chromatography, eluting with 10 to 50% ethyl acetate in isohexane to afford the product (19.3 g, 52%).

後処理

  1. washwashed sequentially with water (2×200 mL) and saturated brine (200 mL)
  2. dry with materialThe organic layer was dried (MgSO4)
  3. customevaporated
  4. customThe residue was purified by flash silica chromatography
  5. washeluting with 10 to 50% ethyl acetate in isohexane

出典と根拠

ORDレコード
ord-c3e8a6411ea7432b85eed9fffce967b1
出典データセット
uspto-grants-2012_03
特許番号
US08143263B2

関連ノート

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