N-[1-(3-Pentafluoroethyl-phenyl)-vinyl]-acetamide → 1-(3-Pentafluoroethyl-phenyl)-ethylamine

HRID 1098750

反応式

HRID 1098750 の反応式
[F:1][C:2]([F:19])([C:7]1[CH:8]=[C:9]([C:13]([NH:15]C(=O)C)=[CH2:14])[CH:10]=[CH:11][CH:12]=1)[C:3]([F:6])([F:5])[F:4]>CO>[F:1][C:2]([F:19])([C:7]1[CH:8]=[C:9]([CH:13]([NH2:15])[CH3:14])[CH:10]=[CH:11][CH:12]=1)[C:3]([F:4])([F:6])[F:5]

参加物

3

反応物 1

HCID 59506293N-[1-(3-Pentafluoroethyl-phenyl)-vinyl]-acetamide

生成物 1

HCID 723100481-(3-Pentafluoroethyl-phenyl)-ethylamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of N-[1-(3-Pentafluoroethyl-phenyl)-vinyl]-acetamide (110 mg, 0.39 mmol) in methanol (10 ml) was added (+)-1,2-bis((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium (I) trifluoromethanesulfonate (0.3 mg). The reaction mixture was hydrogenated with H2 at 5 bar and evaporated. The residue was dissolved in ethanol and hydrochloric acid (6 M, 0.7 ml) and the solution was refluxed for 2 days. Purification by preparative HPLC and lyophilization of the relevant fractions gave the desired product.

後処理

  1. customevaporated
  2. dissolutionThe residue was dissolved in ethanol
  3. temperaturehydrochloric acid (6 M, 0.7 ml) and the solution was refluxed for 2 days
  4. customPurification by preparative HPLC and lyophilization of the relevant fractions

出典と根拠

ORDレコード
ord-68bd9dcb77a841f693a53736ac5ad86d
出典データセット
uspto-grants-2012_03
特許番号
US08143242B2

関連ノート

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