[OH:1][C@H:2]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C@@H:3]([NH:7]C(=O)OC(C)(C)C)[CH2:4][CH2:5][CH3:6].O.[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH2:7][C@@H:3]([CH2:4][CH2:5][CH3:6])[C@@H:2]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[OH:1]The pure tert-butyl (1R,2S)-1-hydroxy-1-phenylpentan-2-ylcarbamate was dissolved in ethyl acetate (1.2 ml). Water (50 μl) and hydrochloric acid in ethyl acetate (1.0 ml, 1.5 M) were added. The solution was stirred at 50° C. for 90 min. A precipitation was formed. The volume was reduced to ⅔ by heavy stirring and a stream of argon gas. The stirring was continued for 1 h at r.t. The suspension was filtered and the solid was dried at 50° C. under reduced pressure for 2 h.
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