(1R,2S)-2-amino-1-phenylpentan-1-ol hydrochloride → (1R,2S)-2-amino-1-(3-methoxyphenyl)pentan-1-ol hydrochloride

反応式

[ClH:1].N[C@@H](CCC)[C@@H](C1C=CC=CC=1)O.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([C:23](=[O:36])[C@@H:24]([NH:28]C(=O)OC(C)(C)C)[CH2:25][CH2:26][CH3:27])[CH:20]=[CH:21][CH:22]=1>>[ClH:1].[NH2:28][C@@H:24]([CH2:25][CH2:26][CH3:27])[C@@H:23]([C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([O:16][CH3:15])[CH:18]=1)[OH:36]

参加物

反応物 2

HCID 12843463(1R,2S)-2-amino-1-phenylpentan-1-ol hydrochloride

HCID 59339638(S)-tert-butyl 1-(3-methoxyphenyl)-1-oxopentan-2-ylcarbamate

生成物 1

HCID 66812884(1R,2S)-2-amino-1-(3-methoxyphenyl)pentan-1-ol hydrochloride

実験手順

was synthesised in the same way as 91b from (S)-tert-butyl 1-(3-methoxyphenyl)-1-oxopentan-2-ylcarbamate (213 mg, 0.693 mmol).

出典と根拠

ORDレコード: ord-83ab5589824b4aefadf2790d52aac922
出典データセット: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08143290B2

反応ノート

読み込み中…