Hydrochloric Acid → (2S)-2-Amino-1-(3-fluorophenyl)-4-methyl-pentane-1-ol hydrochloride
反応式
C(OC(=O)[NH:7][C@H:8]([CH:13]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=1)[OH:14])[CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[NH2:7][C@@H:8]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:13]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=1)[OH:14]参加物
4
実験手順
The aforementioned described {(S)-1-[(3-fluorophenyl)-hydroxymethyl]-3-methylbutyl}-carbamic acid tert.-butylester (4.7 g, 15.1 mmol) is dissolved in dioxane (37 mL). After addition of HCl in dioxane (37.7 mL of a 4M solution) the reaction mixture is stirred for 4 h. After evaporation of the solvent the crude product (3.7 g, 99.5%) is used in the next step without further purification.
後処理
- customAfter evaporation of the solvent the crude product (3.7 g, 99.5%)
- customis used in the next step without further purification
出典と根拠
- ORDレコード
- ord-33d0d70da74d44d4b320ea9fe1757286
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08143290B2
反応ノート
読み込み中…