Ammonia → 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetamide

HRID 1098930ノート

反応式

HRID 1098930 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:19]([O:21]C)=O)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH3:29]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:19]([NH2:29])=[O:21])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 59339649methyl 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetate

生成物 1

HCID 593397222-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetamide

実験手順

A suspension of methyl 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetate (137c, 75 mg, 200 μmol) in methanolic NH3 (7 M, 1 ml) was stirred at r.t. overnight to give a clear solution. Then the solvent was removed in vacuo, and the crude product was freeze-dried go give white solid material, 60 mg (83%).

後処理

  1. customto give a clear solution
  2. customThen the solvent was removed in vacuo
  3. dry with materialthe crude product was freeze-dried go
  4. customgive white solid material, 60 mg (83%)

出典と根拠

ORDレコード
ord-1f4c560bce3740a9ac3af0765c852a8b
出典データセット
uspto-grants-2012_03
特許番号
US08143290B2

反応ノート

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