Hydrochloric Acid → Hydrochloric Acid

HRID 1098991

反応式

HRID 1098991 の反応式
[O:1]1[C:5]2[CH:6]=[C:7]([C@@H:10]([OH:21])[C@H:11]([NH:13]C(=O)OC(C)(C)C)[CH3:12])[CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.[ClH:22]>CCOC(C)=O>[NH2:13][C@H:11]([CH3:12])[C@@H:10]([C:7]1[CH:8]=[CH:9][C:4]2[CH2:3][CH2:2][O:1][C:5]=2[CH:6]=1)[OH:21].[ClH:22]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 59339796t-Butyl (1R,2R)-1-(2,3-dihydrobenzofuran-6-yl)-1-hydroxypropan-2-ylcarbamate

生成物 2

HCID 313Hydrochloric Acid収率 98%HCID 66812942(1R,2R)-2-amino-1-(2,3-dihydrobenzofuran-6-yl)propan-1-ol

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

t-Butyl (1R,2R)-1-(2,3-dihydrobenzofuran-6-yl)-1-hydroxypropan-2-ylcarbamate (1.58 g, 5.39 mmol) was stirred in a solution of HCl in EtOAc (1M, 20 ml) at 60° C. for 2 h. After cooling the solid precipitate was filtered and dried to afford the subtitle compound as hydrochloride (1.22 g, 98%).

後処理

  1. temperatureAfter cooling the solid precipitate
  2. filtrationwas filtered
  3. customdried

出典と根拠

ORDレコード
ord-1909e949f81d4a8db81a81b187bb24c4
出典データセット
uspto-grants-2012_03
特許番号
US08143290B2

関連ノート

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