Hydrazine → HCID 59216295、化合物

HRID 1099028ノート

反応式

HRID 1099028 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]3O[C:15]([NH2:17])=[N:14][N:13]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[NH2:18][NH2:19]>O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]3[N:18]([NH2:19])[C:15]([NH2:17])=[N:14][N:13]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 9321HydrazineHCID 592162905-[1-(4-Methoxyphenyl)cyclopropyl]-1,3,4-oxadiazol-2-amine

生成物 1

HCID 59216295HCID 59216295、化合物収率 47.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
190 °C

実験手順

A mixture of 5-[1-(4-methoxyphenyl)cyclopropyl]-1,3,4-oxadiazol-2-amine (0.60 g, 2.6 mmol), and hydrazine (0.64 mL, 20 mmol) in water (2.0 mL) was heated at 190° C. for 3 h. After cooling to RT, the mixture was further cooled with ice-water. The crystalline solid formed was collected by filtration, washed with water, and dried under high vacuum to yield the desired product (300 mg, 47.1%). Analytical LCMS: (M+H)+=246.1.

後処理

  1. temperatureAfter cooling to RT
  2. customThe crystalline solid formed
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customdried under high vacuum

出典と根拠

ORDレコード
ord-aa51eaead1b9426999e80cf49b01e943
出典データセット
uspto-grants-2012_03
特許番号
US08143251B2

反応ノート

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