Toluene → Methyl 4-(diethoxyacetyl)benzoate
反応式
[O:1]=[CH:2][C:3]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)=[O:4].C([O-])([O-])[O:16][CH2:17][CH3:18].[C:21]1(C)C=CC=C[CH:22]=1>O.C1(C)C=CC(S(O)(=O)=O)=CC=1>[CH2:21]([O:1][CH:2]([O:16][CH2:17][CH3:18])[C:3]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)=[O:4])[CH3:22]参加物
5
実験手順
A mixture of methyl 4-(oxoacetyl)benzoate (13.5 g, 0.0702 mol), ethyl orthoformate (29 mL, 0.18 mol), p-toluenesulfonic acid monohydrate (0.7 g) in toluene (150 mL) was heated under reflux for 2 h. After cooling, the solvent was removed under reduced pressure. The crude material was flash chromatographed on a silica gel column to afford the desired product (15.4 g, 82%). Analytical LCMS: (M+Na)+=289.0.