反応式
[C:1]([O:5][C:6](=[O:13])[NH:7][C@H:8]([CH3:12])[C:9]([NH2:11])=[S:10])([CH3:4])([CH3:3])[CH3:2].Cl[CH2:15][C:16](=O)[CH3:17]>C(O)C>[C:1]([O:5][C:6](=[O:13])[NH:7][C@@H:8]([C:9]1[S:10][CH:15]=[C:16]([CH3:17])[N:11]=1)[CH3:12])([CH3:4])([CH3:2])[CH3:3]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of tert-butyl[(1R)-2-amino-1-methyl-2-thioxoethyl]carbamate (100 mg, 0.49 mmol) with 3 equivalents of chloroacetone (0.135 g) in ethanol (1 mL) was heated at 80° C. for 2 h. After cooling, the solution was concentrated. The residue was dissolved in DCM (1 ml). To the solution was added TFA (1 mL). The mixture was stirred at RT for 30 min. The volatiles were removed under reduced pressure to yield desired product.
後処理
- temperatureAfter cooling
- concentrationthe solution was concentrated
- dissolutionThe residue was dissolved in DCM (1 ml)
- additionTo the solution was added TFA (1 mL)
- customThe volatiles were removed under reduced pressure
出典と根拠
- ORDレコード
- ord-8da26c2187ea407e9446fd2a4484fb8a
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08143251B2
関連ノート
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